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Acupuncture Research Library

Evidence-based studies and clinical research on acupuncture efficacy

Featured ResearchCase StudyChronic Pain

Integrative Korean medicine intervention incorporating angelica gigas for refractory chronic fibromyalgia: A clinical case report.

A 6-week integrative Korean medicine treatment centered on high-dose Angelica gigas produced clinically significant improvements in pain, function, and quality of life in a patient with 10-year treatment-refractory fibromyalgia unresponsive…

February 1, 2026·Explore (New York, N.Y.)
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Meta-AnalysisChronic Pain

Efficacy of Selective Serotonin Reuptake Inhibitors for the Treatment of Chronic Pain and Comorbid Depression in Individuals With Fibromyalgia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

SSRIs significantly reduced pain and depression in fibromyalgia compared to placebo, but showed no significant advantage…

CureusRead More →
Randomized Controlled TrialChronic Pain

Laterality-Dependent Biological Effects of Manual Acupuncture Stimulation of the Auricular Vagus Nerve in Women with Fibromyalgia: A Randomized, Sham-Controlled Trial.

Left-sided auricular vagus nerve stimulation reduced pro-inflammatory cytokines and increased anti-inflammatory markers …

Pain medicine (Malden, Mas…Read More →
Randomized Controlled TrialChronic Pain

Effects of 36.5 Hz pulsed LASER acupuncture on pain and disease impact in fibromyalgia patients: A pilot randomized clinical trial.

Laser acupuncture at 36.5 Hz pulsed frequency applied to Ryodoraku points significantly reduced pain intensity and fibro…

Clinical rheumatologyRead More →
Research StudyChronic Pain

Eicosapentaenoic acid alleviates fibromyalgia-like pain by modulating microglia, astrocytes, and toll-Like receptor 4 signaling in the mice cerebellum.

Oral EPA supplementation significantly reduced fibromyalgia-like pain in mice by decreasing neuroinflammatory markers an…

Nutritional neuroscienceRead More →
Research StudyChronic Pain

Electroacupuncture Relieves Fibromyalgia Pain in a Female Mouse Model by Augmenting Cannabinoid Receptor 1 Expression and Suppressing Astrocyte and Microglial Activation in Nociceptive Pathways.

Electroacupuncture effectively reduced fibromyalgia-associated mechanical and thermal hyperalgesia by upregulating canna…

BiomedicinesRead More →
Research StudyChronic Pain

Integrative and Complementary Health Practices for Chronic Pain: summary of clinical guideline recommendations.

Acupuncture, osteopathy, chiropractic, and yoga received strong recommendations specifically for low back pain, with fav…

Epidemiologia e servicos d…Read More →
Research StudyArthritis

Effects of acupuncture on the signs and symptoms of people with rheumatic diseases: A scoping review.

Acupuncture provided significant pain relief, improved quality of life, enhanced joint function, and reduced depression …

Complementary therapies in…Read More →
Research StudyChronic Pain

Acupressure attenuates fibromyalgia central sensitization via MAPK phosphorylation-mediated neuroinflammation regulation.

Acupressure significantly reduced fibromyalgia pain sensitivity by inhibiting MAPK phosphorylation, suppressing glial ce…

Journal of orthopaedic sur…Read More →
Research StudyChronic Pain

Guidelines on Treating Fibromyalgia With Nonpharmacological Therapies in China.

Acupuncture and health education are strongly recommended as core therapies for fibromyalgia based on moderate-quality e…

Journal of evidence-based …Read More →
Research StudyChronic Pain

Myofascial Pain Syndrome: An Update on Clinical Characteristics, Etiopathogenesis, Diagnosis, and Treatment.

Acupuncture and dry needling demonstrate effectiveness for myofascial pain syndrome compared to placebo, with sufficient…

Muscle & nerveRead More →
Meta-AnalysisChronic Pain

Effect of Physical Activity on Chronic Widespread Pain: Insights From Meta-Analysis and Two-Sample Mendelian Randomization.

Physical activity interventions over three months significantly reduced pain perception and improved quality of life in …

Journal of pain researchRead More →
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