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Ultrasound-guided acupotomy for cervical spondylosis: a systematic review and meta-analysis based on GRADE quality assessment.

Frontiers in pain research (Lausanne, Switzerland)·November 2025·Zhang Lijian, Zhang Zhen, Yuan Yuan et al.
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Key Finding

Ultrasound-guided acupotomy improved clinical effectiveness by 17% and significantly reduced pain compared to conventional treatments for cervical spondylosis, though with notable study heterogeneity.

What This Means For You

Researchers conducted a comprehensive review of 33 studies to determine whether ultrasound-guided acupotomy—a technique combining acupuncture with a specialized needle-scalpel tool guided by ultrasound imaging—effectively treats cervical spondylosis, commonly known as neck arthritis or degenerative neck disease. This condition causes neck pain, stiffness, and limited movement that affects daily activities.

The analysis included patients aged 18-70 and compared ultrasound-guided acupotomy to conventional treatments like physical therapy and standard acupuncture. Researchers measured pain levels, neck disability, range of motion, and overall treatment effectiveness.

The findings showed that ultrasound-guided acupotomy significantly improved treatment success rates by 17% compared to control treatments. Patients experienced meaningful pain reduction, with scores dropping nearly one point on the standard pain scale. The technique also showed moderate improvements in neck function and range of motion, though results varied across studies.

What does this mean for patients? Ultrasound-guided acupotomy appears more effective than conventional treatments for managing cervical spondylosis pain and disability. The ultrasound guidance allows practitioners to precisely target affected tissues in real-time, potentially explaining the superior results. However, the technique requires specialized equipment and training beyond traditional acupuncture.

Important limitations include significant variation between studies and potential publication bias, meaning more research with standardized protocols is needed to confirm these benefits. The quality of evidence was rated as high for overall effectiveness but lower for specific outcomes like pain scores due to inconsistencies between studies.

If you're considering ultrasound-guided acupotomy for neck problems, seek a qualified practitioner with specific training in both acupotomy techniques and ultrasound-guided procedures.

Clinical Notes for Practitioners

This systematic review and meta-analysis evaluated ultrasound-guided acupotomy (UgA) for cervical spondylosis across 33 randomized controlled trials identified through systematic database searches. The intervention group received UgA while controls received placebo, physical therapy, or conventional acupuncture treatments in patients aged 18-70.

Primary outcomes demonstrated UgA significantly improved clinical effective rates (RR=1.17, 95% CI: 1.13-1.21, I²=12%) with high-quality GRADE evidence. Pain reduction showed statistical significance (WMD=-0.96, 95% CI: -1.25 to -0.67) but substantial heterogeneity (I²=91.6%). Secondary outcomes including NDI, CROM, and vertebral/basilar artery mean flow velocity showed moderate improvements with considerable heterogeneity.

GRADE assessment rated clinical effective rate evidence as high quality, while VAS, NDI, and CROM evidence quality was low to very low due to heterogeneity and publication bias concerns. The Cochrane Risk of Bias 2.0 tool assessed study quality.

Clinical takeaway: UgA demonstrates superior efficacy over conventional treatments for cervical spondylosis-related pain and disability, though requires real-time ultrasound guidance and specialized practitioner training. Standardized protocols in future multinational RCTs are needed to address heterogeneity concerns.

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