Global trends in research on miRNA-microbiome interaction from 2011 to 2021: A bibliometric analysis.

This study analyzed global research trends on how tiny genetic molecules called microRNAs interact with the trillions of bacteria living in our gut (the microbiome). Researchers examined 590 scientific papers published between 2011 and 2021 to understand what scientists have been discovering about this important relationship. The analysis found that research in this area has grown significantly over the past decade, with most studies focusing on specific microRNAs (like miR-21 and miR-155) and gut bacteria (like E. coli and Bifidobacterium). The findings show that the interaction between microRNAs and gut bacteria plays important roles in several health conditions, particularly colorectal cancer, inflammatory bowel diseases like Crohn's disease and ulcerative colitis, and neurological disorders including anxiety and Parkinson's disease. For patients considering acupuncture, this research is relevant because traditional Chinese medicine has long recognized the importance of gut health and its connection to overall wellness. The gut-brain axis that this research explores aligns with acupuncture's holistic approach to treating conditions like anxiety, digestive disorders, and inflammatory diseases. The study suggests that targeting this microRNA-microbiome interaction could lead to new treatment approaches, and some research indicates that treatments produced naturally in the body (like through dietary fermentation) may be more stable and effective than synthetic versions. If you're interested in acupuncture for digestive, inflammatory, or neurological conditions, seek care from a licensed acupuncturist with experience in these areas.

This bibliometric analysis examined 590 publications from 2011-2021 on microRNA-microbiome interactions using the Web of Science Core Collection database. Data analysis utilized R package bibliometrix and VOSviewer for visualization. China led in publication volume while the US generated highest citation counts. Key research foci included specific miRNAs (miR-21, miR-155, miR-146a), gut microbes (Escherichia coli, Bifidobacterium, Fusobacterium nucleatum), and metabolites (butyric acid). The three primary disease categories identified were cancer (particularly colorectal), inflammatory bowel disease (Crohn's disease, ulcerative colitis), and neurological disorders (anxiety, Parkinson's disease). Clinical relevance: The miRNA-microbiome axis represents a bidirectional communication pathway relevant to conditions commonly treated with acupuncture, including GI disorders, anxiety, and inflammatory conditions. The study notes that in vivo fermentation methods may enhance miRNA stability compared to synthetic approaches, suggesting dietary and probiotic interventions warrant clinical consideration. This supports integrative treatment protocols addressing gut-brain-immune axis dysregulation.