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[Effect of Tiaojing Cuyun acupuncture therapy on pregnancy outcomes in women with diminished ovarian reserve undergoing IVF-ET: a cohort study].

Zhongguo zhen jiu = Chinese acupuncture & moxibustionยทJune 2024ยทYang Bai, Zhilan Chen, Aidong Gong et al.
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Key Finding

Women with diminished ovarian reserve who received 12 weeks of acupuncture before IVF-ET had a clinical pregnancy rate of 53.8% compared to 17.9% in controls, representing a more than five-fold increase in pregnancy odds.

What This Means For You

Researchers in China studied whether acupuncture could help women with diminished ovarian reserve (DOR) who were undergoing in vitro fertilization and embryo transfer (IVF-ET). DOR means a woman has fewer eggs available or reduced egg quality, which can make pregnancy more difficult. The study included 78 women with DOR, divided into two groups. One group received standard IVF-ET treatment, while the other group received a specific type of acupuncture called "Tiaojing Cuyun" (acupuncture for regulating menstruation and promoting pregnancy) before their IVF-ET procedure. The acupuncture treatment used specific points including Baihui, Shenting, Guanyuan, and others, administered three times per week for 12 weeks. The results were significant: women who received acupuncture had a clinical pregnancy rate of 53.8% compared to just 17.9% in the control group. The acupuncture group also showed improvements in several important fertility markers, including more eggs retrieved, more high-quality embryos, better embryo implantation rates, and higher live birth rates. Additionally, the acupuncture group had lower levels of follicle-stimulating hormone (FSH), which can indicate better ovarian function. The women receiving acupuncture were over five times more likely to achieve clinical pregnancy than those who didn't receive acupuncture. This study suggests that acupuncture may be a valuable complementary therapy for women with DOR undergoing IVF treatment. If you're considering acupuncture for fertility support, seek a licensed acupuncturist with experience in reproductive health.

Clinical Notes for Practitioners

This cohort study evaluated Tiaojing Cuyun acupuncture therapy in 78 women with diminished ovarian reserve undergoing IVF-ET (39 per group after dropouts). The acupuncture protocol involved alternating point prescriptions including GV 20, GV 24, GB 13, CV 12, CV 4, bilateral ST 25, BL 23, and BL 32, administered three times weekly for 12 weeks prior to IVF-ET. The primary outcome, clinical pregnancy rate, was significantly higher in the acupuncture group (53.8% vs 17.9%, P<0.05). Secondary outcomes favoring acupuncture included increased oocyte retrieval, MII oocytes, transferable and high-quality embryos, HCG positivity, embryo implantation, and live birth rates (all P<0.05). Serum FSH and FSH/LH ratios decreased significantly in the treatment group. Logistic regression demonstrated a 5.33-fold increase in clinical pregnancy odds (95%CI: 1.90-14.97, P=0.001). No significant differences were observed in gonadotropin usage, cycle cancellation, E2 levels, or AFC. These findings suggest acupuncture may substantially improve IVF outcomes in DOR patients.

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