Effect of the Mixed Herbal Medicines Extract (Fennel, Chamomile, and Saffron) on Menopause Syndrome: a Randomized Controlled Clinical Trial.

Menopause can bring uncomfortable symptoms that affect daily life, including hot flashes, mood changes, and urogenital discomfort. Iranian researchers studied whether a combination of three herbal medicines—chamomile, fennel, and saffron—could help women manage these symptoms naturally. The study involved 120 women between ages 45 and 65 who were going through perimenopause. Participants were divided into four groups: one received a placebo (inactive drops), while three groups received different doses of the herbal mixture taken daily as oral drops for 12 weeks. The researchers measured changes in physical symptoms (like hot flashes and joint pain), psychological symptoms (like irritability and anxiety), and urogenital symptoms (like vaginal dryness). The results showed that the highest dose group experienced significant improvements across all three areas. Physical symptom scores dropped dramatically from 8.5 to 2, psychological scores decreased from 12 to 2, and urogenital scores improved from 6.5 to 3 after 12 weeks. A medium dose also showed benefits, though less pronounced. The lowest dose and placebo showed no significant changes. The study suggests that this specific herbal combination at higher doses may offer meaningful relief for menopause symptoms without reported side effects. While these herbs show promise, they represent just one approach to managing menopause. If you're interested in integrative approaches to menopausal health, consult with a qualified practitioner who can assess your individual needs and recommend appropriate treatments.

This randomized, triple-blind, placebo-controlled trial (n=120) evaluated a mixed herbal extract of chamomile, fennel, and saffron for menopause symptom management in perimenopausal women aged 45-65 over 12 weeks. Participants were allocated to four groups: placebo, low-dose (250mg/30mg/15mg), high-dose (1000mg/120mg/60mg), and medium-dose (500mg/60mg/30mg). Primary outcome was Menopause Rating Scale scores across physical, psychological, and urogenital domains. The high-dose group (B) demonstrated statistically significant improvements (p<0.001) across all domains: physical scores decreased from median 8.5(IQR 4) to 2(3), psychological from 12(4) to 2(2), and urogenital from 6.5(3) to 3(2). Medium-dose group (D) showed modest improvements (p<0.001). Effect size was 0.92, indicating large clinical significance. Low-dose and placebo groups showed no significant changes. These findings suggest dose-dependent efficacy of this herbal combination for comprehensive menopause symptom relief, offering an evidence-based phytotherapeutic option for integrative menopause management.