Key Finding
This correction notice updates the methodology of a randomized controlled trial protocol studying opposing needling for knee osteoarthritis, but does not report clinical outcomes.
This publication is a correction notice for a previously published research protocol, meaning it does not contain new study results. The original study protocol describes a planned clinical trial investigating "opposing needling" - a specific acupuncture technique - for treating knee osteoarthritis. Knee osteoarthritis is a common joint condition that causes pain, stiffness, and reduced mobility, particularly affecting older adults. The correction indicates that improvements have been made to the original study design to ensure better research quality. The actual clinical trial is designed to test whether this particular acupuncture needling method can effectively reduce knee pain and improve function in people with osteoarthritis. The study will be a randomized controlled trial, which is considered the gold standard in medical research for determining whether a treatment truly works. Once the trial is completed and results are published, patients and practitioners will have better evidence about whether opposing needling is an effective treatment option for knee osteoarthritis. Until then, this correction simply ensures the research will be conducted with the most rigorous methodology possible. Patients interested in acupuncture for knee osteoarthritis should consult with a licensed acupuncturist or qualified practitioner to discuss current treatment options based on existing evidence.
This is a correction notice for a previously published randomized controlled trial protocol examining opposing needling (a traditional acupuncture technique) for knee osteoarthritis treatment. The correction does not present clinical results but indicates methodological improvements to the original study design published in Frontiers in Medicine. The trial protocol aims to evaluate the efficacy of opposing needling compared to control interventions in patients with knee osteoarthritis. Specific details regarding sample size, outcome measures, intervention parameters, and statistical analysis plans would be found in the original and corrected protocol papers. As this is a protocol correction rather than a results publication, no effect sizes or clinical outcomes are available. Clinicians should await the completed trial results before incorporating findings into clinical practice. The correction suggests enhanced rigor in the study methodology, which should improve the reliability of forthcoming results regarding this traditional acupuncture technique for knee osteoarthritis management.
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Find a practitioner โ๐ Patients with AG/GG genotypes at GABRB3 rs4906902 demonstrated significantly superior analgesic responses to acupuncture treatment for knee osteoarthritis compared to AA carriers, associated with reduced striatal gray matter volume and elevated GABRB3 expression.
๐ Singapore developed seven evidence-based recommendations for knee osteoarthritis management using GRADE methodology with patient partnership, addressing gaps in conservative treatment uptake and providing guidance on appropriate use of complementary therapies.
๐ Isopsoralen alleviated osteoarthritis through dual mechanisms of MAPK/NF-ฮบB pathway inhibition and gut microbiota modulation, with fecal transplantation experiments confirming that changes in gut bacteria were essential for therapeutic efficacy.