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Adding Acupuncture to Touch/Relaxation for Pain in Wartime: A Randomized Controlled Trial.

Journal of pain and symptom managementยทMarch 2026ยทEran Ben-Arye, Jan Vagedes, Sameer Kassem et al.
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Key Finding

Manual relaxation therapy with or without acupuncture reduced pain in cancer patients living in a war zone, with no additive analgesic effect from acupuncture, though acupuncture produced distinct heart rate variability changes indicating enhanced parasympathetic activity.

What This Means For You

Researchers in northern Israel studied whether adding acupuncture to touch and relaxation therapy could help cancer patients manage pain while living in a war zone. The study included 125 cancer patients who were randomly divided into two groups: one received manual relaxation therapy plus acupuncture, while the other received only manual relaxation therapy. Both groups showed significant improvements in pain, anxiety, depression, and fatigue immediately after treatment. Interestingly, after three weeks, the group that received relaxation therapy without acupuncture actually reported greater pain reduction on standard assessment tools. However, the acupuncture group showed unique changes in heart rate variability, suggesting increased parasympathetic nervous system activity and decreased stress response. This means their bodies shifted toward a more relaxed state at a deeper physiological level. The study demonstrates that integrative oncology treatments can effectively reduce pain even in extremely stressful circumstances like living in a war zone. While acupuncture didn't provide additional pain relief compared to manual relaxation therapy alone in this study, it did produce distinct effects on the nervous system that may offer other benefits. Both approaches proved valuable for symptom management in cancer patients facing extraordinary challenges. If you're considering acupuncture for cancer-related pain, consult with a licensed acupuncturist who has experience treating oncology patients.

Clinical Notes for Practitioners

This prospective, randomized controlled trial examined integrative oncology interventions in 125 cancer patients in northern Israel during wartime. Patients received manual-relaxation therapy either with acupuncture (n=67) or without (n=58). Both groups demonstrated significant immediate improvements in ESAS pain scores (Group A: P<0.001; Group B: P=0.002), along with anxiety, depression, and fatigue. At three weeks, Group B (no acupuncture) showed superior outcomes on ESAS pain (P=0.039) and MYCAW pain-related concerns (P=0.025). However, Group A exhibited significant HRV changes indicating enhanced parasympathetic activity: decreased LN Power Total (P=0.006), LN Power LF (P=0.02), and LN Power VLF (P=0.026), with marginal increase in Relative Power HF (P=0.054). Clinical takeaway: While acupuncture provided no additive analgesic benefit over manual-relaxation therapy, it produced distinct autonomic nervous system modulation suggesting decreased sympathetic tone, which may offer complementary therapeutic value in oncology populations.

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