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Acupuncture is an effective alternative to medication for migraine: An umbrella review.

Journal of integrative medicineยทOctober 2025ยทPaulo Alexandre Pereira, Carlos Miguel Marto, Bárbara Oliveiros et al.
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Key Finding

Acupuncture significantly reduced both pain intensity and migraine days per month compared to standard medication, with effects persisting three months after treatment cessation and superior tolerability.

What This Means For You

Researchers conducted a comprehensive umbrella review to determine whether acupuncture is an effective alternative to standard medications for treating migraines. They searched major medical databases for systematic reviews comparing acupuncture to pharmacological treatments in patients with episodic or chronic migraines. The review included 22 systematic reviews covering 24,635 patients of all ages. The results showed that acupuncture significantly reduced pain intensity and decreased the number of migraine days per month compared to standard medication. These benefits persisted even three months after acupuncture treatment ended. Most importantly, acupuncture demonstrated better tolerability than medications, meaning patients experienced fewer unwanted side effects. The researchers found that acupuncture works through multiple mechanisms, including its pain-relieving effects, excellent safety profile, and ability to modulate neural pathways in the brain. While the quality of the included studies ranged from low to moderate, and there was variation in results across different studies, the overall evidence supports acupuncture as a safe and effective option for migraine prevention and treatment. For people who experience migraines, this research suggests acupuncture should be considered as a preventive treatment option, particularly when conventional medications aren't working well, when there are medical reasons to avoid medications, or when patients prefer non-pharmaceutical approaches. The findings are especially encouraging for those seeking alternatives to long-term medication use with potentially troublesome side effects. If you're considering acupuncture for migraine management, seek treatment from a licensed and qualified acupuncture practitioner.

Clinical Notes for Practitioners

This umbrella review synthesized 22 systematic reviews encompassing 24,635 patients to evaluate acupuncture's effectiveness versus standard pharmacological treatment for migraine. Researchers searched five major databases through February 2024, including only systematic reviews of randomized controlled trials. Meta-analysis demonstrated statistically significant reductions favoring acupuncture for pain intensity (SMD: -2.17; 95% CI [-3.25; -1.10]; P<0.001) and migraine days per month (SMD: -2.92; 95% CI [-4.65; -1.20]; P<0.001), though with high heterogeneity. Benefits persisted at 3-month follow-up. Acupuncture demonstrated superior tolerability compared to medications. Response rate and adverse event outcomes did not reach statistical significance. AMSTAR 2 assessment revealed low to moderate quality among included reviews with moderate overlap. GRADE evaluation was applied to assess certainty of evidence. Clinical implications: Acupuncture represents a viable first-line or adjunctive treatment for migraine prevention, particularly when pharmacological options are contraindicated, ineffective, or patient preference favors non-pharmacological interventions.

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