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Acupuncture for Anxiety, Depression, and Sleep in Veterans with Combat-Related Posttraumatic Stress Disorder: A Randomized Controlled Trial.

Journal of clinical medicine·May 2025·An-Fu Hsiao, Jennifer Lai-Trzebiatowski, Tyler Smith et al.
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Key Finding

Both verum and sham acupuncture produced significant improvements in anxiety, depression, and insomnia in combat veterans with PTSD, with verum acupuncture yielding a large effect size for anxiety (d=1.3), though no statistically significant difference was found between the two groups.

What This Means For You

If you or a loved one is a veteran struggling with anxiety, depression, or sleep problems after combat, you may be wondering whether acupuncture could help. A new clinical study published in the Journal of Clinical Medicine looked at exactly that question — and the results are encouraging.

Researchers at the Tibor Rubin VA Medical Center in Long Beach, California, recruited 93 combat veterans diagnosed with post-traumatic stress disorder (PTSD). Participants were randomly assigned to receive either traditional acupuncture (called "verum" acupuncture) or a lighter "sham" version using minimal needling. Both groups attended one-hour sessions twice a week for up to 15 weeks, completing as many as 24 sessions total.

The researchers measured changes in anxiety, depression, and sleep quality before, during, and after treatment using widely recognized clinical rating scales.

Here's what they found: both groups improved significantly. Veterans receiving traditional acupuncture showed a large reduction in anxiety symptoms, and those receiving sham acupuncture showed a moderate reduction. Depression and sleep quality improved in both groups as well. Perhaps most notably, very few participants dropped out — suggesting acupuncture is a well-tolerated option compared to some medications, which often come with side effects or high dropout rates.

One nuance worth noting: while both approaches worked, the study did not find a statistically significant difference between real and sham acupuncture. This is an active area of scientific debate, and researchers believe more studies are needed to understand how acupuncture produces its effects and how long those benefits last.

For veterans and others living with PTSD-related anxiety, depression, or insomnia, this study adds meaningful evidence that acupuncture may be a safe and effective complementary treatment option.

If you're considering acupuncture, look for a licensed acupuncturist with experience treating trauma, anxiety, or PTSD-related conditions.

Clinical Notes for Practitioners

This single-blinded, two-arm RCT (n=93 combat veterans; 71 completers) evaluated verum versus sham acupuncture for anxiety, depression, and insomnia in PTSD patients at a VA outpatient center. Participants received up to 24 sessions over 15 weeks. Primary outcomes were measured via the Hamilton Anxiety Rating Scale, Beck Depression Inventory, and Pittsburgh Sleep Quality Index at pre-, mid-, and post-intervention timepoints. General Linear Models were applied in both ITT and completer analyses. Verum acupuncture produced a large effect size for anxiety (d=1.3); sham produced a moderate effect (d=0.9). Both arms demonstrated clinically meaningful improvements across all three outcome domains, with no statistically significant between-group differences. Withdrawal rates were notably low. Clinical takeaway: acupuncture — including minimal needling controls — shows robust efficacy for PTSD-associated anxiety, depression, and insomnia. These findings support acupuncture as a well-tolerated adjunct treatment warranting further investigation into mechanisms and long-term durability.

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