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Acupoint Stimulation After Anesthesia Induction Does Not Decrease Nausea and Vomiting After Hepatectomy: A Multi-Center Double-Blinded Clinical Trial.

Journal of investigative surgery : the official journal of the Academy of Surgical ResearchΒ·December 2026Β·Shan He, Zhifeng Lv, Hongxia Wang et al.
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Key Finding

Intraoperative acupoint stimulation at PC6 did not reduce postoperative nausea and vomiting in hepatectomy patients receiving standard antiemetic therapy, though it decreased patient-controlled analgesia requirements.

What This Means For You

Researchers in China studied whether acupoint stimulation could help reduce nausea and vomiting after liver surgery. This multi-center study involved 159 patients who were scheduled for elective hepatectomy (liver removal surgery) at three major hospitals. All patients received standard anti-nausea medications, and half were randomly assigned to also receive transcutaneous electrical acupoint stimulation (TEAS) at the PC6 acupoint on the wrist during surgery, while the other half received no stimulation.

The study found that TEAS did not significantly reduce the occurrence of postoperative nausea and vomiting within 24 hours after surgery. About 24% of patients who received TEAS experienced nausea and vomiting, compared to 27% in the control groupβ€”a difference that was not statistically meaningful. Recovery times, including when patients could walk and when normal digestive function returned, were also similar between groups.

However, the study did reveal one interesting benefit: patients who received TEAS needed fewer doses of pain medication after surgery. They pressed their pain medication pump fewer times and received fewer doses overall compared to the control group.

What this means for patients: If you're having liver surgery, acupoint stimulation during the operation likely won't prevent nausea and vomiting when combined with standard anti-nausea drugs. However, it might help reduce your need for pain medication afterward, which could be beneficial. More research is needed to confirm this pain-relief effect and determine the best way to use acupoint stimulation in surgical settings. If you're interested in acupuncture or acupoint stimulation for surgical recovery, consult with a licensed acupuncturist experienced in perioperative care.

Clinical Notes for Practitioners

This multicenter, double-blinded RCT conducted across three Chinese tertiary hospitals evaluated transcutaneous electrical acupoint stimulation (TEAS) at PC6 during hepatectomy as an adjunct to standard double-antiemetic prophylaxis. Among 159 patients who completed the study, intraoperative TEAS did not significantly reduce 24-hour postoperative nausea and vomiting (PONV) incidence compared to controls (23.8% vs. 26.6%; OR 0.86, 95% CI: 0.42-1.76). PONV severity and recovery parameters including time to ambulation and gastrointestinal function recovery showed no significant differences between groups. However, the TEAS group demonstrated reduced patient-controlled analgesia (PCA) requirements, with fewer attempts (2.7 vs. 3.5) and deliveries (2.6 vs. 3.5) at 24 hours postoperatively. Clinical takeaway: While intraoperative PC6 stimulation appears ineffective for PONV prevention when added to antiemetic protocols in hepatectomy patients, its potential analgesic-sparing effects merit further investigation for optimizing multimodal perioperative analgesia strategies.

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